We previously found that miR-212-3p transfers from pancreatic cancer cells to dendritic cells via exosomes, inhibiting expression of RFXAP and major histocompatibility complex (MHC) class II molecules and leading to immune tolerance of dendritic cells15 miR-212-3p is upregulated in PDAC and is correlated with TNM stage and poor prognosis16–18. The gene discussed is RFXAP; the disease is familial pancreatic carcinoma.