CD4 and cancer: In recent years, immune cell therapy has been applied more and more to tumor therapy.20,21 In TME, T cells are a key component, and treatment with ICIs or adoptive cell infusion has led to breakthroughs in cancer therapy.22 Most clinical application of T cells was centered on αβ T cells (CD4+, CD8+ T cells), γδ T cells are also important players in cancer immunity.23 γδ T cells constitute 0.5–16% of total CD3+ cells in the peripheral blood.