In TME, T cells are a key component, and treatment with IHI or adoptive cell has led to breakthroughs in cancer therapy.37,38 γδ T cells share many qualities with their αβ T-cell counterparts, such as cytotoxic effector functions and pro-inflammatory cytokine production, but one major difference between γδ T cells and αβ T cells is their relative dependence on MHC molecules. Here, HLA-C is linked to cancer.