KLRK1 and neoplasm: This finding was consistent with the previous report by Alnaggar et al.28 In addition to increase of lymphocytes, the levels of IL-2, IFN-γ, and TNF-β were also improved, suggesting a stronger antitumor efficacy.20 As we all know, NKG2D plays an important role in identifying and killing tumor, IRE plus γδ T cells could markedly upregulated NKG2D.