Fu et al.184 found that lncRNA HOX transcript antisense intergenic RNA (Hotair) was significantly upregulated in NPC cells and clinical specimens, which can directly enhance the VEGF transcription activity, or indirectly enhance the VEGFA transcription activity and angiopoietin 2 (Ang2) activity through GRP78, mediating angiogenesis and tumor growth in NPC. This evidence concerns the gene HSPA5 and nasopharyngeal carcinoma.