The main therapeutic methods are to restore the function of p53 and to interfere with the p53–MDM2 axis.308 By reviewing recent studies on PI3K/Akt pathway and p53 pathway in NPC, we have summarized some potential targets that can affect the PI3K/Akt pathway and p53 pathway, which will be conducive to the selection of targeted therapeutic targets for NPC in future basic studies. The gene discussed is MDM2; the disease is nasopharyngeal carcinoma.