The Ca2+ channel blocker skf96365 can inhibit the colony formation and increase the cell death rate by interfering with the Ca2+ signal induced by EGF, and induce the apoptosis and cell cycle arrest of G2/M and S-phase in CNE-2 and HONE-1 cells through caspase pathway.202 NaBu can promote SOCE in 5-8F and 6-10B cells to increase Ca2+ inflow and induce apoptosis in NPC cells.203 In addition, the overexpression of WW domain-containing oxidoreductase (WWOX) gene can also promote apoptosis by accumulating the cleavage of Caspase 3.204. The gene discussed is WWOX; the disease is nasopharyngeal carcinoma.