STAT3 and cancer: It is reported that IL-6 can activate lncRNA DANCR through the STAT3 pathway, forming a positive feedback loop, enhancing the invasion and proliferation ability of NPC cells in vitro.153 Liu et al.154 indicated that ovatodiolide could significantly inhibit the JAK2/STAT3 signal pathway, upregulate the level of Bax and Slug and decrease the level of Bcl-xL, c-Myc, and cyclin D1, which significantly reduces the cancer stem cell characteristics of NPC cells together with survival, proliferation, invasion, migration, and EMT inhibited, and promote the apoptosis of NPC cells.