LMP1 can induce lipid synthesis mediated by sterol regulatory element-binding protein 1 (SREBP1) through the mTOR signal pathway to promote cell proliferation and tumor invasion.64 LMP2A-mediated activation of the PI3K/Akt/mTOR/HIF-1α signal cascade can lead to vasculogenic mimicry (VM).65 Here, AKT1 is linked to neoplasm.