Leucine zipper tumor suppressor 2 (LZTS2) can inhibit the activation of PI3K/Akt signal pathway causing the inhibition of tumorigenesis and radioresistance in NPC.93 LMP1 can increase miR-155 expression and miR-155–UBQLN1 axis can affect the proliferation, cell cycle, and EMT progression of NPC cells by activating PI3K/Akt pathway.94 MiR-18a can activate mTOR by targeting and downregulating suppressor of morphogenesis in genitalia 1 (SMG1), which is an antagonist of mTOR in NPC. Here, AKT1 is linked to nasopharyngeal carcinoma.