AMPK/mTOR/HIF-1 pathway can regulate the angiogenesis and glycolysis of NPC, and the microRNA-BART1-5P encoded by EBV acts on the α1 catalytic subunit of AMPK to regulate tumor metabolism and angiogenesis.201 The aberrant regulation of store-operated Ca2+ entry (SOCE) is highly associated with the process of NPC. Here, HIF1A is linked to neoplasm.