LMP1 is believed to activate the NF-κB signal pathway.106 In EBV-associated NPC cells, LMP1-activated NF-κB binds to the promoter region of the miR-203 gene and inhibits miR-203 expression, Cadherin 6 (CDH6) as a direct target of miR-203 upregulates in turn induced EMT and promotes metastasis. Here, CDH6 is linked to nasopharyngeal carcinoma.