PIK3CA and cancer: The PI3K/Akt pathway, which has an important role in NPC, can be activated by the EGF signal, and there are currently targeted drugs such as Cetuximab that target EGFR.236 Inhibitors of components in the PI3K/Akt pathway have been used to treat other cancers, and further studies are needed to determine whether they are appropriate for the treatment of NPC.