NF-κB is a key multipotent dimer transcription factor.104 Studies have shown that the activation of the NF-κB pathway is closely related to persistent infection of EBV, the formation of immortal nasopharyngeal epithelial cells and immunosuppressive environment, cancer stem cells generation, and metabolic reprogramming.105 Through the WES, several NF-κB signaling negative regulators NFKBIA, CYLD, and TNFAIP3 were found multiple loss-of-function mutations. This evidence concerns the gene NFKB1 and cancer.