PIK3CA and nasopharyngeal carcinoma: PBK can promote the growth of NPC in nude mice and HI-TOPK-032, the specific inhibitor for PBK/TOPK, can significantly reduce the volume and weight of NPC in nude mice without obvious signs of toxicity.145 In Wong et al.’s273 research, the tumor weight of mice treated with the PI3K-mTOR dual inhibitor PF-0469150210 is significantly reduced when compared with the control group.