The extracellular-signal-regulated kinases (ERK)/NF-κB pathway is suppressed after RERG demethylation activation, which results in downregulating the expression of MMPs and pro-angiogenic cytokines, reducing the proliferation, migration, invasion, colony formation, and angiogenesis of NPC cells.122 Being a key active subunit of the NF-κB pathway, p65 is closely involved in the deregulation of the NF-κB pathway.123 Li et al.124 found that Epigallocatechin-3-gallate (EGCG) could inhibit NF-κB p65 activity, thus suppressing cancer progression, which is relevant to CSCs and EMT. Here, NFKB1 is linked to cancer.