BST2 and cancer: In the view of the key role of inhibitor of NF-κB kinase (IKK) in the activation of the NF-κB pathway, IKK inhibitor is considered as one of the strategies of targeted therapy for cancer.110 The natural flavonoid glycoside vitexin can inhibit the activity of IKK thereby inhibiting the activation of the NF-κB signal pathway and inducing NPC cell apoptosis.111 BST2, also known as CD317 or HM1.24, is found to be highly expressed in cisplatin-resistant NPC cells.