Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), as an important signal regulator, is associated with EBV infection.140 Xu et al.141 found that PIN1 was overexpressed in EBV-associated NPC cells and PIN1 inhibitors Juglone could eliminate the PIN1 effect of activating the MAPK/JNK pathway, reducing the downstream protein cyclin D1 expression and enhancing the activity of caspase 3, finally inhibiting proliferation. This evidence concerns the gene MAPK8 and nasopharyngeal carcinoma.