Given that several interventions that inhibit PM repair also inhibit T. cruzi invasion (Chakrabarti et al., 2003; Fernandes et al., 2011; Fernandes et al., 2007; Reddy et al., 2001), we examined the impact of EndoA2 depletion on the susceptibility of WT and Cav1 KO MEFs to infection by these parasites. This evidence concerns the gene CAV1 and infection.