As an additional measure of Treg function, we compared Treg in control, non-regressor and regressor tumors for expression of PD1 and LAG3 (figure 5F, G).36 The pattern of expression within and between tumor types was noteworthy in so much that a high proportion of PD1+ cells corresponded with a low proportion of LAG3+ cells and vice versa, implying a degree of compensatory expression by the two receptors. Here, LAG3 is linked to neoplasm.