MAPT and supranuclear palsy, progressive, 1: Our study has numerous strengths, including assessment of two missense AD risk variants in two large autopsy-confirmed LBD-NP and PSP cohorts, investigating their effects on LBD-NP sub-categories representing different levels of LB and AD pathologies, detailed analyses of Aß and tau as endophenotypes including quantitative tau neuropathologies in 841 PSP patients.