In summary, in our study of 973 LBD-NP and 1040 PSP autopsy-confirmed patients, we find evidence that the protective effect of PLCG2_rs72824905-G may be driven by suppressing tau especially in the earlier stages of its cortical deposition and may require presence of another proteinopathy, such as Aß to confer reduced disease risk. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.