Rare, missense variants ABI3_rs616338-T and PLCG2_rs72824905-G were associated with respectively higher (OR = 1.43) and lower (OR = 0.68) risk of Alzheimer’s disease (AD) in a large study comprised of 48,402 cases and 37,022 controls [22]. This evidence concerns the gene PLCG2 and Alzheimer disease.