CXCR1 and infection: The remaining genes of the locus encode chemokine receptors of the C-C and CXC families which are defined based on the position of the two conserved cysteine residues in the N-termini of these members of the superfamily of G protein-coupled receptors (GPCRs); chemokines control cell migration associated with immune surveillance by trafficking effector cells to sites of infection and inflammation [10].