Potential associations between the genetic variability in major histocompatibility complex (MHC) class I genes (human leukocyte antigen [HLA] A, B, and C) and the susceptibility to SARS-CoV-2 and severity of COVID-19 were investigated by Nguyen et al. who performed a comprehensive in silico analysis of viral peptide-MHC class I binding affinity across 145 HLA-A, HLA-B, and HLA-C genotypes for all SARS-CoV-2 peptides [15]. Here, HLA-C is linked to COVID-19.