MYC and cancer: After Wnt ligands bind to Frizzled and other co-receptors on the cell surface, β-catenin is stabilized and translocates into the nucleus, where it interacts with TCF/LEF transcription factors in a context-dependent manner to regulate the expression of multiple protein-coding genes such as MYC and AXIN2. Dysregulation of Wnt signaling is found in multiple cancers.