The results of the present study revealed that the serum levels of TNF-α, IL-8, IL-6, and TGF-β1 were higher in the secondary group than in the uterine fibroids group, and the differences in the levels of TNF-α, IL-6, IL-8 and TGF-β1 in serum between these two groups were statistically significant. The gene discussed is TGFB1; the disease is uterine corpus leiomyoma.