According to the previous large-scale literature-based approach selected for identification of novel stroke-related genes, no prior direct relations to the pathogenesis of stroke were known for SP1. However, Pathway Studio-guided the ‘shortest path’ revealed multiple pathways connecting SP1 and stroke (Fig. 2), which were supported by at least one reference (See DVT_Stroke→ShortestPath). Here, SP1 is linked to Stroke.