LEP and Stroke: As shown in Fig. 2, SP1 promotes 7 inhibitors of stroke, including PTGS2, L10, IGF1, LEP, ENTPD1, HSPA1A and HIF1A. However, the literature-based pathways also suggested that SP1 could inhibit three stroke-promoters (IL1B, TGFB1, and ACE), which was not supported by the 11 datasets employed in this study (these genes demonstrated increased expression levels in the case of increased SP1 expression).