PIK3CA and central nervous system cancer: The results showed that the hub targets were highly related to PI3K-AKT signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, focal adhesion, cell cycle, and tumor-related pathways, such as melanoma, glioma, non-small cell lung cancer, pancreatic cancer, prostate cancer, and proteoglycans in cancer (Figure 4(b)).