Both mouse models, Epm2a−/−, lacking laforin expression [32] and Epm2b−/−, null for malin expression [33], have symptoms similar to those observed in patients with the disease, such as motor alterations, memory deficits, dyskinesia, epilepsy, neurodegenerative processes and Lafora bodies, which have been extensively characterized in previous reports [32,33,34,35]. This evidence concerns the gene EPM2A and memory.