In this study, we analysed the role of Rab5 and Rab7 proteins, which regulate the early and late endosome, as well as Rab11, which is part of the recycling pathway in the early endosome [35,36] and exocytosis [37], on the regulation of the NALP3 inflammasome in a CRC cell line, HCT116. Here, NLRP3 is linked to colorectal carcinoma.