Among pathways with significant alteration only at baseline, the apoptosis pathways emerged with survival genes hyperexpressed both in the patient with monogenic SLE (#1) and in the patient with sporadic SLE (#6); in patient #2, affected with CANDLE syndrome, it was worth noting the downregulation of PI3K-AKT pathway, which might be related to the severe lipodystrophy of the girl, if we hypothesize that a similar change can occur in adipocytes as well [31]; in patients #4, #5, #6, #7, IFN-related signaling is one of the main pathway significantly altered at baseline. This evidence concerns the gene AKT1 and systemic lupus erythematosus.