Given the diagnosis of monogenic lupus-like interferonopathy and considering a strikingly elevated IFN score, we started off-label use of JAKinhibs, in combination with two antimalarials (hydroxychloroquine and mepacrine), allowing prompt resolution of headaches, significant improvement of arthritis, sparing of glucocorticoids and growth-hormone induced catch-up. Here, IFNA1 is linked to Arthritis.