Likewise, histone deacetylase 6 (HDAC6), a protein involved with aggresome formation in neurodegenerative diseases, is also upregulated in prion infection and is suggested to increase autophagy through modulation of the PI3K-Akt-mTOR signaling pathway, resulting in neuronal protection against PrPSc [137]. Here, HDAC6 is linked to neurodegenerative disease.