MAPK8 and non-small cell lung carcinoma: It has also been reported that the inhibition of TRPM2 could accelerate the cancer cells death by increasing the intracellular ROS in non-small cell lung (NSCLC) cells [75]; the impairment of autophagy through the JNK-signaling in gastric cancer cells [76]; or reducing the G2/M ratio in the proliferation cycle of leukemia cells [77] and NSCLC cells [75].