Consistent with this view, the TRPM2 channel has been found to be highly expressed in numerous cancers including bladder, breast, head and neck, lung, pancreatic, prostate, melanoma, and neuroblastoma [51], among which most studies were focused on the neuroblastoma [58,59,60,61,62,63,64] (Figure 2). This evidence concerns the gene TRPM2 and cancer.