Unfortunately, and although there is a well-known enlargement of spleens in lupus-prone MRL/lpr mice [44], it was not possible to obtain enough CMA+ and CMA− lysosomes separately, even by pooling 4–5 spleens, as attested by the low amount of lysosomes (measured by the expression of LAMP2A and glucocerebrosidase, GBA) recovered in the CMA+ fraction and unusually high levels of HSPA8 in the CMA− fraction (Figure S3). The gene discussed is GBA1; the disease is systemic lupus erythematosus.