Interestingly, although the isolation of lysosomes from spleen yielded a very low recovery unsuitable for to carry out the uptake experiments we planned, immunoblots of those fractions also demonstrated an increase in HSPA8 and LAMP2A in the CMA− lysosomes from MRL/lpr spleens (Figure 3) suggesting that the imbalance toward CMA+ lysosomes may be a systemic feature in lupus. Here, HSPA8 is linked to systemic lupus erythematosus.