There was a two-fold increase in PPARγ transcriptional activity as well as PPARγ protein expression after treatment with curcumin both in vitro (PPARγ activity: 4.0 vs. 2.0 AU; protein expression: 0.9 vs. 0.3 AU) and in vivo models of AD (PPARγ activity: 4.5 vs. 2.0 AU; protein expression: 1.0 vs. 0.3 AU) [226]. The gene discussed is PPARG; the disease is Alzheimer disease.