TNF and Alzheimer disease: Daily long term supplementation with 200 mg/kg BW of TRF in APPswe/PS1dE9 AD mouse model for six months caused significant downregulation of 3615 genes compared to AD control mice that included decreased expressions of the Hdac2 and Iqgap2 genes, which were involved in the inflammatory process via TNF-α/NF-κB signaling pathway [239].