Not only did 15 μM resveratrol increased Nrf2 gene expression, it also initiated Nrf2 translocation in the nucleus resulted in the increased in the mRNA and protein expression of heme oxygenase-1 (HO-1) (increased intensity on 1.0% agarose gel electrophoresis and western blot analysis, respectively), on PC 12 cells models of PD. Here, HMOX1 is linked to Parkinson disease.