SOD2 and Alzheimer disease: The result was corroborated by another study in lymphoblastoid cell lines of AD patients, whereby 50 μM of resveratrol treatment significantly upregulated the gene expression of the antioxidant system including CAT, SOD2, and NFE2L2 compared to AD control (relative mRNA expression: 3 vs. 1, 2.5 vs. 1, and 2.5 vs. 1, respectively) [169].