However, in a cohort of 211 de novo DLBCL patients MYC protein overexpression did not correlate with CD40 gene expression, but an association was shown with decreased levels of the co-stimulatory immune checkpoint OX40 (TNFRSF4) gene, decreased T cell receptor signaling molecules and regulatory T cell gene FOXP3 [60]. This evidence concerns the gene TNFRSF4 and diffuse large B-cell lymphoma.