In about 30% of the MYC translocated DLBCL patients, this is the only translocation (single hit (SH) DLBCL), while in the majority MYC translocations are accompanied by a translocation affecting either the BCL2 or BCL6 gene, referred to as double-hit (DH) high grade B cell lymphoma (HGBL), or both BCL2 and BCL6 genes, referred to as triple hit (TH) HGBL [1]. The gene discussed is MYC; the disease is high grade B-cell lymphoma.