During PTB infection, the development of focal, multifocal, and diffuse paucibacillary lesions has been associated with an intense Th1 cell-mediated immune response with a predominance of pro-inflammatory cytokines such as TNF-α, IL-1, IL-6, and IL -23 [9,39,40], which, at the same time, are the main stimulus for APPs production at the hepatic level [41]. Here, TNF is linked to infection.