SIRT3 and obesity due to melanocortin 4 receptor deficiency: Further establishing the link between SIRT3, mitochondria, and obesity, mice with SIRT3 deletion while exposed to a HFD displayed weight gain and brain protein hyperacetylation, microglial activation, neuroinflammation, and defective mitochondrial respiration that are more pronounced than those in HFD-fed obese wildtype (WT) mice [63].