KNG1 and Sepsis: Other suitable immunohistochemical markers characterized by the decrease of their expression in sepsis cases compared to controls, include: VEGF [33], involved in neoangiogenesis and vascular permeability; VEC [35,36], a cell–cell adhesion molecule involved in the endothelial barrier remodeling in response to an inflammatory insult; ACE [35], which is also involved in the modulation of the bradykinin system; sarcoglycan [39], involved in sarcolemmal stabilization, whose levels decrease in septic heart.