In line with the Sirius Red staining, the expression of Col1a1 remained unaltered, but we detected a trend towards higher levels of the fibrosis marker Timp1 after ICD feeding (warm CD vs. warm ICD, p = 0.063; cold CD vs. cold ICD p = 0.017) (Figure 5G). The gene discussed is COL1A1; the disease is impulse control disorder.