Previous studies demonstrated that whole-body insulin sensitivity could be improved by supplementation with medium doses (9 g/day) of L-arginine to patients with visceral obesity and/or T2DM, as well as high fat diet-treated rodents, leading to increase of glucose uptake, normalized hepatic arterial and portal blood flows, as well as microcirculation, increased hepatic tissue oxyhemoglobin, and further enhanced cellular resistance to oxidative stress [15]. The gene discussed is INS; the disease is type 2 diabetes mellitus.