Furthermore, marked accumulation of L-arginine, glucose metabolites, phosphocreatine, and SAM are proven to be the very important metabolic characteristics of T2DM/NASH-associated liver tumors, which are likely to be related to activation of oxidative stress resistance, cellular methylation, β-catenin, mTOR pathways, and cell proliferation. Here, MTOR is linked to type 2 diabetes mellitus.