OTC and metabolic dysfunction-associated steatohepatitis: In addition, accordingly to the data obtained from IPA and Gene Expression Omnibus (GEO) database (GSE63067), except for CDAHFD diet model, enzymes of urea cycle including ARG1, ASL, ASS1, and OTC are similarly downregulated in TSOD, Stelic Animal Model (STAM), MAT1, and GNMT knockout (KO) mice NASH models, which are all characterized by altered SAM production [26].