FGF2 and neoplasm: Its binding to tumor cells forces the flipping of the “angiogenic switch,” causing the expression of several important angiogenic proteins and cytokines in the platelet’s ECM, including fibroblast growth factor-2 (FGF-2), matrix metalloproteinase MMP-2, platelet-derived growth factor (PDGF), and vascular endothelium growth factor (VEGF) [27].