CSF2 and dengue disease: In fact, this increase in hematopoiesis and subsequent forcing of progenitor cells from the bone marrow as a result of increased cytokines, such as interleukin (IL)-3, IL-7, and granulocyte macrophage colony stimulating factor (GM-CSF) [19] may be the mechanism behind the “break bone” symptom, a commonly cited symptom of dengue where patients report severe bone pain [17].