Ultimately, eight lncRNAs (MIR4435-2HG, LINC02541, MIR9-3HG, AC104083.1, AC099850.4, PTOV1-AS2, AC245041.2, AL357033.4) were screened to compose a prognostic signature for HNSCC. Here, PTOV1 is linked to head and neck squamous cell carcinoma.