Based on analysis of sample data from the TCGA and GTEx databases (426 tumor and 88 normal) in GEPIA (http://gepia.cancer-pku.cn), the upregulated of PLEC and downregulation of TNS2 in tumor tissues was found, which further validated the expression trend of the GSEA results (Figure 7D, 7E). This evidence concerns the gene TNS2 and cancer.