TRIM28 and breast cancer: However, in two other cohorts (GSE9893 and GSE11121) [40, 41] that respectively included 155 and 200 samples at different stages of breast cancer, lower TRIM28 expression was associated with poorer OS or distant metastasis-free survival (DMFS) (OS HR = 0.80, 95% CI = 0.68 to 0.95, Cox p = 0.008; DMFS HR = 0.34, 95% CI = 0.13 to 0.89, Cox p = 0.028; Respectively; Figure 5D, 5E).