The mechanisms by which tumor-infiltrating B cells influence tumor immunity may include: 1) functioning as antigen-presenting cells to facilitate innate cellular immunity in the TIME; 2) activating CD8+ T cells to promote antigen-specific antitumor immune responses [60]; and 3) promoting adaptive immunity by inducing the release of circulating cytokines to recruit immunosuppressive cells [61]. The gene discussed is CD8A; the disease is neoplasm.