Recent analysis of melanoma exome data revealed novel melanoma genes such as protein phosphatase 6 catalytic subunit (PPP6C), Ras-related C3 botulinum toxin substrate 1(RAC1), sorting Nexin 31(SNX31), transforming acidic coiled-coil containing protein 1 (TACC1), serine/threonine kinase 19 (STK19) and AT-rich interactive domain-containing protein 2 (ARID2) [8]. This evidence concerns the gene RAC1 and melanoma.