MAPT and amyloidosis: In the amyloid cascade hypothesis, in a complex pathway of events, amyloidosis leads to cognitive decline via synaptic dysfunctioning (amyloid plaques), and in the tau hyperphosphorylation hypothesis, in a complex pathway of events, extensive phosphorylation of tau leads to cognitive decline via microtubule dysfunctioning (neurofibrillary tangles) (Fan et al., 2019).