APC and Carcinoma, Lewis Lung: Both, subcutaneous injection of Lewis lung carcinoma cells (LLC, yellow colour code) and genetic mutation of the Apc locus (ApcMin/+, green colour code), the latter inducing spontaneous intestinal tumourigenesis with ageing,17 led to a strong modification in the circulating lipid profile associated with the development of cachexia as indicated by PLS‐DA (Figures1B and S1A–S1F, experiments 4 and 5).