MAPT and Alzheimer disease: Neuropathologically, AD is typified by progressive, age‐dependent accumulation of amyloid β‐protein (Aβ; Sperling et al., 2020) in both soluble and insoluble plaque conformations, as well as neurofibrillary tangles mostly comprised of hyperphosphorylated tau, leading to vast synaptic and neuronal degeneration (De Strooper & Karran, 2016; Hardy et al., 1998; Li et al., 2020).