For example, Hv1 KO mice exhibited less glial activation, decreased production of pro‐inflammatory cytokines, and an M2‐dominant polarization phenotype in models of ischemic stroke, chronic hypoperfusion, multiple sclerosis, and spinal cord injury (Li et al., 2020; Liu et al., 2015; L. J. Wu et al., 2012; Yu et al., 2020). Here, HVCN1 is linked to ischemic stroke.