rs192879175 is 1.5 kb 3′ of CBLC, sits within enhancer histone marks and a DNase I hypersensitivity site in liver, and is predicted to alter a transcription factor binding site motif.51 Similarly, rs143764218 is 8.7 kb 3′ of CEACAM16, sits within promoter/enhancer histone marks and DNase I hypersensitivity site across multiple tissues, and is predicted to alter 7 transcription factor binding site motifs.51 Neither rs192879175 nor rs143764218 has previously been shown to be associated with AD or other traits by GWAS,54 perhaps owing to their uncommon allele frequencies. This evidence concerns the gene CBLC and Alzheimer disease.