This discordance between observed and imputed ε2 and ε4 genotypes may have led to spurious associations with AD; there was a nominal association between imputed genotypes at rs429358 and AD after APOE adjustment (model 2 OR, 1.16; 95% CI, 1.00-1.34; P = .04) and among ε3 homozygotes (model 3 OR, 1.73; 95% CI, 1.26-2.38; P = 6.32 × 10−4). The gene discussed is APOE; the disease is Alzheimer disease.