CEACAM16 and Alzheimer disease: rs192879175 is 1.5 kb 3′ of CBLC, sits within enhancer histone marks and a DNase I hypersensitivity site in liver, and is predicted to alter a transcription factor binding site motif.51 Similarly, rs143764218 is 8.7 kb 3′ of CEACAM16, sits within promoter/enhancer histone marks and DNase I hypersensitivity site across multiple tissues, and is predicted to alter 7 transcription factor binding site motifs.51 Neither rs192879175 nor rs143764218 has previously been shown to be associated with AD or other traits by GWAS,54 perhaps owing to their uncommon allele frequencies.