Associations with AD were found for rs2075650 (odds ratio [OR], 2.59; 95% CI, 2.45-2.75; P = 3.19 × 10−228) and rs4420638 (OR, 2.77; 95% CI, 2.62-2.94; P = 2.99 × 10−254) without APOE adjustment. This evidence concerns the gene APOE and Alzheimer disease.