The data within the APOE region includes 14 415 SNVs and 18 795 individuals, of whom 11 167 were women (59.4%) and 7628 were men (40.6%) (median age at onset/evaluation, 76 [interquartile range, 70-82] years); 9704 were affected by AD (51.6%), and 9066 were controls (51.6%) (eTable 1 in the Supplement). The gene discussed is APOE; the disease is Alzheimer disease.