APOE and Alzheimer disease: Each SNV was significantly associated with AD without APOE adjustment (model 1) (OR for rs2075650, 2.59 [95% CI, 2.45-2.75; P = 3.19 × 10−228]; OR for rs4420638, 2.77 [95% CI, 2.62-2.94; P = 2.99 × 10−254]), although these associations weakened with APOE adjustment or stratification.