The association between rs2075650 and AD was nominally significant among ε4 homozygotes (model 4) (OR, 1.33; 95% CI, 1.00-1.77; P = .047) but failed to reach significance after APOE adjustment (model 2; OR, 1.09; 95% CI, 0.99-1.19; P = .07) or among ε3 homozygotes (model 3; OR, 1.16; 95% CI, 0.98-1.38; P = .09). This evidence concerns the gene APOE and Alzheimer disease.