SYP and Alzheimer disease: Though, the latter view is challenged by the finding of lower synaptophysin levels in non‐demented vs. demented PSP subjects (5) as well as by more recent findings, which could not confirm decreased binding of the synaptic vesicle protein 2A (SV2A) targeting radio‐ligand [3H]UCB‐J to presynaptic vesicle pools in postmortem sections of AD patients in comparison to non‐AD control cases (30).