To date, determined toxicity is less assigned to higher molecular aggregates such as sarkosyl‐insoluble tau tangles (~1000 monomers) or filaments than rather to truncated, sarkosyl‐soluble forms like oligomeric (~10–100) tau assemblies, which might precede in early tauopathy disease stages (2, 6, 24). The gene discussed is MAPT; the disease is tauopathy.