Furthermore, an impaired astroglial support has previously been implicated in a pTau‐ and amyloid precursor protein (APP)‐related disease context, including mouse models recapitulating tauopathies with mutant pTau (P301S, P301L (42), rTg4510 (39)), brain culture internalization approaches (38) and the APP‐KO mouse line (31). The gene discussed is APP; the disease is tauopathy.