The neuropathological classification of frontotemporal lobar degeneration of the tau‐type (FTLD‐tau), a group of neurodegenerative diseases with predominant cognitive (frontotemporal dementia, FTD) and motor impairments, primarily bases on heterogeneous patterns of cytoplasmic inclusions of aggregated hyperphosphorylated microtubule‐associated protein tau (pTau) in neurons and glia (9, 16, 18, 27, 48). This evidence concerns the gene MAPT and frontotemporal dementia.