CH25H and infection: Inaddition, 25HC has been identified as a natural ligand for RORyt [71, 72].The fact that PPARy deficiency was linked to CH25H overexpression [73], prompted our initial hypothesis thatT0070907 blocks HIV outgrowth ex vivo and infection invitro and boosts Th17 effector functions via CH25H/25HC-dependentmechanisms.