Of particular importance, T0070907 actedpreferentially on CCR6+ Th17-polarized T cells, a subset known to beenriched in HIV reservoirs in ART-treated PLWH [16, 63], to increase IL-17Aproduction and reduce CCR5 expression and viral replication invitro. Similar to T0070907, the literature documents that PKC-θactivators such as prostratin, a non-tumor-promoting phorbol ester, also acts as anLRA while blocking de novo HIV production to mediate theelimination of HIV reservoirs by a kick and kill strategy [64-67]. Here, CCR5 is linked to neoplasm.