CD4 and HIV infectious disease: Metabolism disruption is associated with HIV disease progression,with higher glucose uptake being observed in CD4+ T cells of PLWHcompared to non-infected individuals [76].Recent studies linked the susceptibility to HIV infection to the metabolic status ofspecific CD4+ T-cell subsets [77].Changes in the CD4+ T-cell metabolic program are controlled by themTORC1/PPARy axis [74, 78].