Remarkably, although choriocarcinoma is part of a spectrum of conditions known as gestational trophoblastic disease: complete and partial hydatidiform mole, invasive mole, choriocarcinoma and placental-site trophoblastic tumor, they show different pattern of angiogenesis expression, for example, while molar gestations produce more anti-angiogenic proteins similar to preeclampsia [46], expression of sFlt-1 is strongly suppressed in choriocarcinoma cell lines and VEGF is highly expressed in these cells [47]. This evidence concerns the gene PROS1 and trophoblastic neoplasm.