The findings on SCWAT pro-inflammatory cytokines; IL-1 β and IL-6 (non-detectable levels) and their up-regulation by diabetogenic diet in female rats reiterate the function of subcutaneous fat in the inflammatory process as reported by several researchers, that contrary to the visceral fat, subcutaneous adipose harbours anti-inflammatory cytokines and offers protection against inflammation-associated metabolic diseases, such as type 2 diabetes and cardiovascular disease, particularly in pre-menopausal women [47,48]. This evidence concerns the gene IL6 and type 2 diabetes mellitus.