In this context, the data of the present study, on some of the depot- and/or sex-specific adipose tissue secretome (such as IL-1β, IL-6, LIF, M-CSF, RANTES and lipocalin-2) and the lipid droplet-associated proteins (perilipins, ABHD5), clearly suggest that these factors may possibly predict the insulin resistance and perhaps, a key role in the development of insulin resistance. This evidence concerns the gene IL6 and Insulin resistance.