Regarding the relationship between tumor PAI‐1 expression and RCC prognosis, IHC staining intensity of cytoplasmic PAI‐1 in paraffin specimens has been previously associated with shorter disease‐free survival, OS, and cause‐specific survival (CSS) in patients with RCC.20, 21, 22, 23, 24, 25. This evidence concerns the gene SERPINE1 and renal cell carcinoma.