However, Trachtenberg et al. (2012) found similar effects of ε4 and ε2 on functional connectivity in a young group and argued that the effects of APOE do not relate only to AD risk, but rather to the putative role of APOE in neurodevelopment (see also Deary et al., 2002; O’Donoghue et al., 2018). Here, APOE is linked to Alzheimer disease.