ACE2 was associated with improved OS in many patients with liver cancer, except for those with stage 2 (HR = 0.65, P = 0.2872), grade 3 (HR = 0.59, P = 0.0839), or American Joint Committee on Cancer stage T2 (HR = 0.71, P = 0.3515) disease, or microvascular invasion (HR = 0.5, P = 0.1322). This evidence concerns the gene ACE2 and liver cancer.