ACE2, as well as Ang 1–7, has been reported to inhibit the growth of lung cancer (Menon et al., 2007; Ni et al., 2012; Qian et al., 2013) and metastasis of prostate cancer (Krishnan et al., 2013b), and it is associated with better prognosis in hepatocellular carcinoma (Ye et al., 2015). Here, ACE2 is linked to Familial prostate cancer.