ACE2 has been implicated in cardiac dysfunction, hypertension (Crackower et al., 2002), heart failure and ventricular remodeling (Donoghue et al., 2003; Zisman et al., 2003), diabetes (Tikellis et al., 2003), Ang 1–7 regulation during pregnancy (Brosnihan et al., 2003), and as a functional receptor for coronaviruses, including SARS-CoV and SARS-CoV-2 (Li et al., 2003; Zhou et al., 2020). This evidence concerns the gene ANGPT1 and hypertensive disorder.