ANGPT1 and Familial prostate cancer: ACE2, as well as Ang 1–7, has been reported to inhibit the growth of lung cancer (Menon et al., 2007; Ni et al., 2012; Qian et al., 2013) and metastasis of prostate cancer (Krishnan et al., 2013b), and it is associated with better prognosis in hepatocellular carcinoma (Ye et al., 2015).