Additionally, a single PSA test lacks potentially important information such as PSA kinetics (PSA velocity and doubling time) and free-to-total PSA ratio, which are potentially important predictors of prostate cancer aggressiveness (Catalona et al., 2000, Carter et al., 1992, Vickers and Brewster, 2012). The gene discussed is KLK3; the disease is Familial prostate cancer.