Combined with all these findings above, it suggested that LINC01234 knockdown might suppress the expression of HIF-2α, and then inhibit the expression of VEGFA, EGFR, c-Myc, Cyclin D1 and MET, which might further inhibit the proliferation, metastasis and then influence the survival of ccRCC patient. This evidence concerns the gene MYC and nonpapillary renal cell carcinoma.