The present study assessed demographics, laboratory data and plasma Granzyme A and Heparin-binding protein levels, detected by ELISA assays, of 43 sepsis patients with AKI (29 patients with AKI stage I, 6 patients with AKI stage II and 8 patients with AKI stage III) and 17 sepsis patients without AKI as controls. The gene discussed is AZU1; the disease is acute kidney injury.