INS and obesity due to melanocortin 4 receptor deficiency: As reviewed in [112], EWAS also showed that differentially methylated genes involved in adipogenesis, lipogenesis, fatty acid oxidation, lipoprotein metabolism as well as insulin signaling and inflammation in sWAT and/or vWAT were related to obesity traits, and about 30% of the methylated loci were further associated with the nearby SNPs, which may suggest a role for SNP-directed DNA methylation and sequential gene expression changes in obesity.