DNMT3A and neoplasm: However, G9a and GLP induce the formation of the DNMT3a-MPP8-GLP/G9a silencing complex through DNMT3a-K44me2 (mouse; K47me2, human) methylation and therefore may facilitate the tumor-suppressive role of DNMT3a (Chang et al., 2011; Lachance et al., 2014).