Drp1 is aberrantly S-nitrosated in neurodegenerative disease as high levels of Drp1-SNO and hyperactive Drp1 are detected in postmortem brains and peripheral blood lymphocytes of AD patients (Cho et al., 2009; Wang et al., 2009; Manczak and Reddy, 2012; Wang S. et al., 2012). The gene discussed is DNM1L; the disease is Alzheimer disease.