The multifunctional protein PDI is also aberrantly S-nitrosated in neurodegenerative conditions as shown in postmortem spinal cords of ALS patients and transgenic SOD1G93A mouse model of ALS as well as in postmortem brains of AD and PD patients (Uehara et al., 2006; Walker et al., 2009; Chen et al., 2013; Jeon et al., 2014; Conway and Harris, 2015; Figure 2D). The gene discussed is P4HB; the disease is amyotrophic lateral sclerosis.