Furthermore, in TCGA dataset, the mRNA level of NEO1 was significantly decreased in colon adenocarcinoma (COAD) (fold change = -−2.411, p = 1.35E-33), rectal adenocarcinoma (READ) (fold change = -−2.450, p = 1.67E-19), cecum adenocarcinoma (CCAD) (fold change = -−2.037, p = 7.71E-10) and colon mucinous adenocarcinoma (CMAD) (fold change = -−2.099, p = 2.69E-8) (Fig. 1B(a-d)). Here, NEO1 is linked to rectum adenocarcinoma.