Recent studies have shown that knockout of PKP1 by CRISPR-Cas9 technique significantly inhibited tumor proliferation and promoted metastasis and dissemination of lung cancer, and PKP1 promoted MYC translation by binding 5′-UTR of MYC mRNA, suggesting that PKP1 was also recognized as an oncogene in lung cancer [33]. The gene discussed is PKP1; the disease is lung cancer.