BRCA1 and cancer: Among the 47 reportable genes from the 59 gene set of ACMG59, variants in cancer-associated genes were the most prevalent in UKB with WES; BRCA2 (93 variants, 166 carriers), BRCA1 (39 variants, 59 carriers), PMS2 (21 variants, 59 carriers) and MSH6 (35 variants, 52 carriers); and variants in LDLR, which is associated with familial hypercholesterolaemia (Mendelian inheritance in man (MIM) code 143890), were the second most prevalent (35 variants, 68 carriers).