Among the 47 reportable genes from the 59 gene set of ACMG59, variants in cancer-associated genes were the most prevalent in UKB with WES; BRCA2 (93 variants, 166 carriers), BRCA1 (39 variants, 59 carriers), PMS2 (21 variants, 59 carriers) and MSH6 (35 variants, 52 carriers); and variants in LDLR, which is associated with familial hypercholesterolaemia (Mendelian inheritance in man (MIM) code 143890), were the second most prevalent (35 variants, 68 carriers). The gene discussed is LDLR; the disease is cancer.