This resource enables us to characterize disease-risk profiles for individuals who carry pathogenic and likely pathogenic variants in medically relevant disease genes, including cancer susceptibility genes, such as BRCA1 and BRCA2. We observed that carriers of pathogenic or likely pathogenic variants had 3.77-fold greater odds of any of the five cancers previously associated with BRCA1 or BRCA2; penetrance for any of the five cancers was 21.1% in carriers compared with 6.6% in non-carriers. The gene discussed is BRCA2; the disease is cancer.